Investigative Urology

Increased mRNA expression of genes involved in pronociceptive inflammatory reactions in bladder tissue of interstitial cystitis - Abstract

Published on Tuesday, 18 June 2013 14:47

PURPOSE: The mRNA expression of transient receptor potential (TRP) family of channels and acid-sensing ion channel 1 (ASIC1) was assayed in bladder tissue of interstitial cystitis (IC).

Somatic alterations contributing to metastasis of a castration resistant prostate cancer - Abstract

Published on Tuesday, 18 June 2013 14:42

Metastatic castration-resistant prostate cancer (mCRPC) is a lethal disease, and molecular markers that differentiate indolent from aggressive subtypes are needed.

CUL3 and NRF2 mutations confer an NRF2 activation phenotype in a sporadic form of papillary renal cell carcinoma - Abstract

Published on Tuesday, 18 June 2013 14:37

Sustained activation of the stress-regulated transcription factor NRF2 (NFE2L2) is a prominent feature of many types of cancer, implying that mutations driving NRF2 may be important to tumor progression.

Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells - Abstract

Published on Tuesday, 18 June 2013 14:33

Extracellular acidification, a mandatory feature of several malignancies, has been mainly correlated with metabolic reprogramming of tumor cells toward Warburg metabolism, as well as to the expression of carbonic anydrases or proton pumps by malignant tumor cells.

Increasing intracellular bioavailable copper selectively targets prostate cancer cells - Abstract

Published on Tuesday, 18 June 2013 14:26

The therapeutic efficacy of two bis(thiosemicarbazonato) copper complexes, glyoxalbis[N4-methylthiosemicarbazonato]Cu^II [Cu^II(gtsm)] and diacetylbis[N4-methylthiosemicarbazonato]Cu^II [Cu^II(atsm)], for the treatment of prostate cancer was assessed in cell culture and animal models.

Toll-like receptor-associated sequence variants and prostate cancer risk among men of African descent - Abstract

Published on Tuesday, 18 June 2013 14:04

Recent advances demonstrate a relationship between chronic/recurrent inflammation and prostate cancer (PCA).

Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts - Abstract

Published on Tuesday, 18 June 2013 13:39

BACKGROUND: Resveratrol (Res) is recognized as a promising cancer chemoprevention dietary polyphenol with antioxidative, anti-inflammatory, and anticancer properties.