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ABSTRACT

Renal cell carcinoma (RCC) with gallbladder metastasis is a very rare entity, whether as a synchronous or metachronous lesion. Additional ancillary immunohistochemical tests may be required to make the diagnosis. We report the case of a 66-year-old woman with primary RCC and a synchronous gallbladder metastasis, who underwent laparoscopic radical nephrectomy and cholecystectomy in the same setting. Gallbladder histopathology revealed clear cell RCC, similar to the primary tumor. With positive immunostaining of the tumor for CA-IX, she has responded well to interleukin-2 immunotherapy.

Keywords: Kidney neoplasm, Gallbladder, Metastasis

Correspondence: J. Stuart Wolf, Jr., University of Michigan, Department of Urology, 1500 East Medical Center Drive, TC 3875, Ann Arbor, MI, 48109, wolfs@umich.edu